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Coronavirus disease (COVID-19) is a public health emergency happening worldwide. It brought tremendous impacts to the global economy and people’s mental health (Jiaqi Xiong et al., 2020). Many people suffered physically and psychologically with the sudden arrival of COVID-19. Among the different age groups, studies identified that undergraduate students as a vulnerable group with a higher risk of mental health problems, such as depression and anxiety (Silva et al., 2022; King et al., 2022; Mansor & Ahmad, 2022). This qualitative study collected data from six focus group interviews with undergraduate students studying in Macao. Thematic analysis was used to understand the COVID-19 impact on students' mental well-being and coping strategies, as well as to explore the protective and risk factors that contribute to students’ mental well-being in the local context of Macao. Results showed four themes with 15 contributory sub-themes: COVID-19’s impact on students’ mental well-being, key impacting sources, coping strategies, and risk and protective factors. This study provides a picture of the mental health condition of undergraduate students during the zero-COVID period in Macao and raises an urgent call for extra attention to university students’ mental health during crises, showing the social and mental needs of undergraduates. This research also uniquely contributes insight into how the dysfunctionality of families could be a significant risk factor for students’ mental health during the crisis, which is rarely found in other COVID-19 studies. This research suggests a promotion of future programs or workshops that would strengthen and benefits students’ relationship with their family. Future research could explore the family function in Macao and its relationship with students’ mental well-being