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The global pandemic triggered by the Corona Virus Disease firstly detected in 2019 (COVID-19), entered the fourth year with many unknown aspects that need to be continuously studied by the medical and academic communities. According to the World Health Organization (WHO), until January 2023, more than 650 million cases were officially accounted (with probably much more non tested cases) with 6,656,601 deaths officially linked to the COVID-19 as plausible root cause. In this Chapter, an overview of some relevant technical aspects related to the COVID-19 pandemic is presented, divided in three parts. First, the advances are highlighted, including the development of new technologies in different areas such as medical devices, vaccines, and computerized system for medical support. Second, the focus is on relevant challenges, including the discussion on how computerized diagnostic supporting systems based on Artificial Intelligence are in fact ready to effectively help on clinical processes, from the perspective of the model proposed by NASA, Technology Readiness Levels (TRL). Finally, two trends are presented with increased necessity of computerized systems to deal with the Long Covid and the interest on Precision Medicine digital tools. Analyzing these three aspects (advances, challenges, and trends) may provide a broader understanding of the impact of the COVID-19 pandemic on the development of Computerized Diagnostic Support Systems.

The scientific literature indicates that pregnant women with COVID-19 are at an increased risk for developing more severe illness conditions when compared with non-pregnant women. The risk of admission to an ICU (Intensive Care Unit) and the need for mechanical ventilator support is three times higher. More significantly, statistics indicate that these patients are also at 70% increased risk of evolving to severe states or even death. In addition, other previous illnesses and age greater than 35 years old increase the risk for the mother and the fetus, including a higher number of cesarean sections, higher systolic and diastolic maternal blood pressure, increasing the risk of eclampsia, and, in some cases, preterm birth. Additionally, pregnant women have more Emotional lability/fluctuations (between positive and negative feelings) during the entire pregnancy. The emotional instability and brain fog that takes place during gestation may open vulnerability for neuropsychiatric symptoms of long COVID, which this population was not studied in depth. The present Chapter characterizes the database presented in this work with clinical and survey data collected about emotions and feelings using the Coronavirus Perinatal Experiences—Impact Survey (COPE-IS). Pregnant women with or without COVID-19 symptoms who gave birth at the Assis Chateaubriand Maternity Hospital (MEAC), a public maternity of the Federal University of Ceara, Brazil, were recruited. In total, 72 mother-infant dyads were included in the study and are considered in this exploratory analysis. The participants have undergone serological tests for SARS-CoV-2 antibody detection and a nasopharyngeal swab test for COVID-19 diagnoses by RT-PCR. A comprehensive Exploratory Data Analysis (EDA) is performed using frequency distribution analysis of multiple types of variables generated from numerical data, multiple-choice, categorized, and Likert-scale questions.

Even with more than 12 billion vaccine doses administered globally, the Covid-19 pandemic has caused several global economic, social, environmental, and healthcare impacts. Computer Aided Diagnostic (CAD) systems can serve as a complementary method to aid doctors in identifying regions of interest in images and help detect diseases. In addition, these systems can help doctors analyze the status of the disease and check for their progress or regression. To analyze the viability of using CNNs for differentiating Covid-19 CT positive images from Covid-19 CT negative images, we used a dataset collected by Union Hospital (HUST-UH) and Liyuan Hospital (HUST-LH) and made available at the Kaggle platform. The main objective of this chapter is to present results from applying two state-of-the-art CNNs on a Covid-19 CT Scan images database to evaluate the possibility of differentiating images with imaging features associated with Covid-19 pneumonia from images with imaging features irrelevant to Covid-19 pneumonia. Two pre-trained neural networks, ResNet50 and MobileNet, were fine-tuned for the datasets under analysis. Both CNNs obtained promising results, with the ResNet50 network achieving a Precision of 0.97, a Recall of 0.96, an F1-score of 0.96, and 39 false negatives. The MobileNet classifier obtained a Precision of 0.94, a Recall of 0.94, an F1-score of 0.94, and a total of 20 false negatives.

The COVID-19 pandemic has posed a significant public health challenge on a global scale. It is imperative that we continue to undertake research in order to identify early markers of disease progression, enhance patient care through prompt diagnosis, identification of high-risk patients, early prevention, and efficient allocation of medical resources. In this particular study, we obtained 100 5-min electrocardiograms (ECGs) from 50 COVID-19 volunteers in two different positions, namely upright and supine, who were categorized as either moderately or critically ill. We used classification algorithms to analyze heart rate variability (HRV) metrics derived from the ECGs of the volunteers with the goal of predicting the severity of illness. Our study choose a configuration pro SVC that achieved 76% of accuracy, and 0.84 on F1 Score in predicting the severity of Covid-19 based on HRV metrics.

The continuous development of robust machine learning algorithms in recent years has helped to improve the solutions of many studies in many fields of medicine, rapid diagnosis and detection of high-risk patients with poor prognosis as the coronavirus disease 2019 (COVID-19) spreads globally, and also early prevention of patients and optimization of medical resources. Here, we propose a fully automated machine learning system to classify the severity of COVID-19 from electrocardiogram (ECG) signals. We retrospectively collected 100 5-minute ECGs from 50 patients in two different positions, upright and supine. We processed the surface ECG to obtain QRS complexes and HRV indices for RR series, including a total of 43 features. We compared 19 machine learning classification algorithms that yielded different approaches explained in a methodology session.

In 2020, the World Health Organization declared the Coronavirus Disease 19 a global pandemic. While detecting COVID-19 is essential in controlling the disease, prognosis prediction is crucial in reducing disease complications and patient mortality. For that, standard protocols consider adopting medical imaging tools to analyze cases of pneumonia and complications. Nevertheless, some patients develop different symptoms and/or cannot be moved to a CT-Scan room. In other cases, the devices are not available. The adoption of ambulatory monitoring examinations, such as Electrocardiography (ECG), can be considered a viable tool to address the patient’s cardiovascular condition and to act as a predictor for future disease outcomes. In this investigation, ten non-linear features (Energy, Approximate Entropy, Logarithmic Entropy, Shannon Entropy, Hurst Exponent, Lyapunov Exponent, Higuchi Fractal Dimension, Katz Fractal Dimension, Correlation Dimension and Detrended Fluctuation Analysis) extracted from 2 ECG signals (collected from 2 different patient’s positions). Windows of 1 second segments in 6 ways of windowing signal analysis crops were evaluated employing statistical analysis. Three categories of outcomes are considered for the patient status: Low, Moderate, and Severe, and four combinations for classification scenarios are tested:  (Low vs. Moderate, Low vs. Severe, Moderate vs. Severe) and 1 Multi-class comparison  (All vs. All)). The results indicate that some statistically significant parameter distributions were found for all comparisons.  (Low vs. Moderate—Approximate Entropy p-value = 0.0067 < 0.05, Low vs. Severe—Correlation Dimension p-value = 0.0087 < 0.05, Moderate vs. Severe—Correlation Dimension p-value = 0.0029 < 0.05, All vs. All—Correlation Dimension p-value = 0.0185 < 0.05. The non-linear analysis of the time-frequency representation of the ECG signal can be considered a promising tool for describing and distinguishing the COVID-19 severity activity along its different stages.

In the last few years, the tourism industry has experienced rapid expansion and diversification, making it one of the fastest-growing financial industries in the world. Consequently, the hotel industry has significantly affected the environment's long-term viability. Many hotels have begun voluntarily implementing environmentally sustainable practices as they become more aware of their ecological footprint. There has been a great deal of discussion about the effects of hotel operations on the environment and tourism sustainability in Macau. It is because of these negative impacts that hoteliers have adopted green practices in an attempt to minimize them. By developing sustainability reports, hotels can set goals, measure performance, and manage change, resulting in better sustainability. It could also be viewed as a strategy to enhance the company’s sustainability reporting to ensure stakeholders know what the company does. The objective of this study is twofold based on the analysis of the official sustainability reports of four major hotel chains. Firstly, seven categories of sustainable practices effectively adopted by these chain hotels are identified and clusterized. Second, it is presented in which areas some hotels performed more efficiently than others, considering the UN Sustainable Development Goals (SDGs) as a reference. The results allow a comprehensive clusterized analysis of the industry in a highly developed gaming and entertainment area of South China and create a clear comparison between relevant players and their concerns about sustainability practices.

Nowadays, the increasing number of medical diagnostic data and clinical data provide more complementary references for doctors to make diagnosis to patients. For example, with medical data, such as electrocardiography (ECG), machine learning algorithms can be used to identify and diagnose heart disease to reduce the workload of doctors. However, ECG data is always exposed to various kinds of noise and interference in reality, and medical diagnostics only based on one-dimensional ECG data is not trustable enough. By extracting new features from other types of medical data, we can implement enhanced recognition methods, called multimodal learning. Multimodal learning helps models to process data from a range of different sources, eliminate the requirement for training each single learning modality, and improve the robustness of models with the diversity of data. Growing number of articles in recent years have been devoted to investigating how to extract data from different sources and build accurate multimodal machine learning models, or deep learning models for medical diagnostics. This paper reviews and summarizes several recent papers that dealing with multimodal machine learning in disease detection, and identify topics for future research.

Molecular Chinese Medicine (MCM) is a recent method of manufacturing and dosing prescriptions that brings several advantages when compared with Traditional Chinese Medicine (TCM). For instance, MCM is highly dissoluble, tastes better than the usual decoction, and the active principles are easily absorbed. Also, the manufacturing process is subject to better quality control. In spite of these benefits, consumers' intentions remain unclear due to the novelty of this technique. Therefore, an assessment of individuals' perceptions is relevant since molecular medicine is redefining how scientists understand and treat diseases, and it can be considered a medical innovation. To fill the research gap, the Value-based Acceptance Model (VAM) (Kim et al., 2007) is used to assess the individuals' perceptions of value and intention to accept MCM. Data from a sample of Macau residents are analyzed by means of structural equation modeling (SmartPLS). The results support the use of the model in our context, thus extending the applicability of the VAM to other settings. Except for 'technicality', the constructs of 'usefulness', 'enjoyment', and 'perceived fee' had a significant impact on the overall 'perceived value' of MCM, and in turn on the behavioral intention to use the innovation. To facilitate the diffusion of this dosage method in the marketplace, it is suggested that communications strategies consider the proposed sources of value when promoting MCM. To further explain the adoption process, it is recommended to include additional factors that may affect consumers' intention to adopt the innovation and extend the analysis to the actual usage.

Citizens' trust in eGovernment is crucial for the successful implementation of new electronic services. This relationship in the Greater Bay Area (GBA) plays an essential role since the Government services rely on mobile mini-programs This study investigates the trust towards government service mini-programs in WeChat and Alipay. A user feedback questionnaire was designed, and a total of 609 valid samples were collected from Shenzhen, Guangzhou, Hong Kong, and Macau. The findings imply that competence, integrity, and benevolence are the key components of trust in e-government (TIEG). TIEG positively influences perceived value (PV), which positively affects citizens' Intention to adopt service mini-programs. PV significantly mediates the relationship between TIEG and Intention. Although TIEG does not effectively reduce perceived risk (PR), risk issues cannot be ignored in the adoption process. Finally, this article proposes relevant implications and suggestions for the GBA government agents and policy makers.

Technology research offers several theories and models to explain how individuals accept and use technology innovations. While these often focus on the technical aspects of the innovation, they tend to downplay the affective component of technology. Recognizing that the adoption of technology is also determined by what it means and represents to the users, this paper aims to fill the gap in the literature by studying the effects of social influence and image on the behavioral intention to adopt a technology. We used structural equation modeling (SmartPLS) to analyze data collected from 238 self-administrated surveys regarding the behavioral intention of Macau residents to use battery electric vehicles. The result showed significant relationships among the variables in the model and depicted the construct of image as a strong factor in the adoption decision. Our findings suggest that social influence may not exhibit substantial impact in the case of innovations in their initial phase and, more importantly, the construct of image could be included as a key predictor of behavioral intention in technology acceptance models, particularly in contexts where the choices that consumers make are public, and therefore subject to judgments from the members of the community.

The Guangdong-Hong Kong-Macau Greater Bay Area (GBA) was first conceptualized in 2016, which aimed to facilitate trade and finance liberalization among the three regions. The trade and financial environment of the GBA is unique. Due to the “one country, two systems” principle, Mainland China, Hong Kong and Macau are considered to be trading partners bounded by WTO rule, but bilateral free trade agreements have been signed between Mainland China and Hong Kong, and between Mainland China and Macau, but not between Hong Kong and Macau. Furthermore, each of the three regions circulates a local currency subject to its own exchange rate policy, with Hong Kong Dollar and Macau Pataca currently pegged to the US Dollar. These affect the mobility of trade and capital flows in the area. Hence, this paper applies the widely-used price-based approach due to Cheung et al. [5] to analyze the degrees of real and financial integration in the GBA based on interest rates, exchange rates, and price indexes data from January, 2016 to November, 2021. The real interest differential (RID), uncovered interest differential (UID) and the deviation from purchasing power parity (PPD) between each regional pair have means that are statistically and economically close to zero, implying high real and financial integration in the GBA. The unit root tests for stationarity also confirm that the time series are mean-reverting, so the economic integration in the GBA in the long run is foreseeable.

Neuromarketing lies at the intersection of three main disciplines: psychology, neuroscience, and marketing, and it has been a successful neuroscientific approach for the study of real-life choices such as consumer behavior [1]. A current gap in the cosmetics field is the lack of published research studies, considering the marketing investment done yearly in this category. With the rapid economic expansion and the rise of social media in China, consumers' interest in beauty is growing. Even though the Chinese cosmetics sector is rapidly expanding, no studies have been done with Chinese consumers. This study aims to employ the same approach as previously done in consumer neuroscience studies to evaluate cosmetic brands' marketing strategy to understand better if immediate emotional responses can be measured using Electrodermal Activity (EDA). Here, we focus on cosmetics products advertisement as a model to understand consumer preference formation and choice. Eighteen Chinese female consumers were recruited between 19 and 37 years old. From the results obtained, it was understood that none of the participants have voted for the product advertisement for which they showed higher emotional arousal. However, it appears that the participants' preference is for the products for which the brand awareness is stronger since the product advertisements with more votes are the ones for the Korean brand used. The product advertisements with Asian faces were the ones with more votes, suggesting that Asian faces have engaged consumer preference. However, the product advertisements for the Brazilian brands, unknown to the Chinese public, were the ones with fewer votes, although, those product advertisements were the ones with more emotional arousal per minute. Those advertisements were also those with non-Asian faces, suggesting that this feature influenced voting decisions. From this study, it has been observed that Electrodermal Activity is a measure of emotional arousal that by itself cannot be translated into consumer engagement. Therefore, it is also proposed to evaluate brand awareness in future studies related to product advertisements. The physical features of the people included in the advertisements is also suggested to be further evaluated in future studies since a different cultural background seems to influence the consumers' engagement. Furthermore, using EDA to complement other neurophysiological tools like facial expression analysis is also suggested for future studies to have evidence about the nature of the emotions raised.

In recent years, entrepreneurship and innovation have been highly propagandised for Macau's economic development, diversification, and the Greater Bay Area (GBA). Since 2013, efforts have been exerted by the Macau government to encourage and support entrepreneurship, from the launching of the Young Entrepreneurs' Aid Scheme in 2013 and the Macau Young Entrepreneur Incubation Centre in 2015. While the failure rate of startups has been considered high in most parts of the world, the rate was only as low as 14% in Macau, with many businesses created every year. This research aims to study the unique entrepreneurial environment for small-to-medium enterprises (SMEs) starting up in Macau from the experience of local entrepreneurs who are benefactors of government support. In-depth interviews were conducted to understand the experience and perceptions of these entrepreneurs as they go through each stage of the entrepreneurial process. Existing research on entrepreneurial processes varies from the two-stage process, which focuses on the beginning of an enterprise, to the different models of various stages from ideas generation to exit or long-term development. From the consolidation of the literature on the entrepreneurial process, five key stages were taken to guide this qualitative research. Findings suggested that idea validation at the start of the entrepreneurial process is almost non-existent amongst our research subjects. Yet it does not affect the implementation and growth of these SMEs. The growth strategies tend to be steady and for the long term, with most SMEs having no consideration of an exit plan.

As the rate of change increases exponentially, organizations must adapt quickly to the business landscape's volatility, uncertainty, complexity, and ambiguity (VUCA). As a result, organizations must implement agile strategies and practices to ensure their responsiveness and readiness to any changes brought about by internal or external factors. With a greater number of changes, change agents are tasked with implementing various change management methodologies to ensure that change recipients accept change initiatives. This research will look at one of the methodologies used by change agents, the use of nudges from Thaler and Sunstein's Nudge Theory, which is a subtle intervention to influence an individual's decision-making with the goal of steering them towards a specific desired outcome; and analyze their effectiveness towards the change recipients when implemented. Change agents were interviewed on the application of Nudge Theory to change recipients when managing to change initiatives within their respective organizations. The results indicate that the use of nudges created by the change agents can significantly impact the level of resistance from the change recipients. If used correctly, the Nudge Theory can mitigate change resistance, and the success of a change initiative is higher. But, if change recipients are forced to comply, their resistance will be greater, affecting the organization overall.

In government studies, electronic government has become a hot topic in recent decades. Many scholars believe that soon, the government might not be able to operate smoothly without the help of ICTs as the Internet has been overwhelming people's daily lives already. In analyzing people's behavioral factors towards adopting e-government services, most studies targeted the adult population, while those in the hard-to-reach groups are minimal. This study was designed especially to understand the behavioral factors of the younger generation aged between 18 and 24 and the senior citizens above 60 on their adoption of e-government services in Macao SAR. Sixteen in-depth interviews were conducted based on the semi-structured interview questions developed from the prior literature on the Theory of Planned Behavior and e-government studies. Six significant findings are yielded, which could serve as an important reference for policymakers designing e-government policy and promoting its implementation strategy. These behavioral factors also contribute empirical data to support the theoretical framework of TPB in the context of Macao SAR e-government services.