Search
Full bibliography 2,190 resources
-
The world is perpetually changing, and the COVID-19 pandemic has taught us that the future is full of unforeseen challenges and potentialities. What are the implications of the advancement in technology on education? How are teachers coping with contemporary educational expectations? Is there a need to redesign the learning environment? What is the exact nature of the forces driving such a change? Is there anything we can learn from successful innovations around the globe? The goals of this dissertation include designing a learning/teaching app and redesigning classroom furniture for primary-level education. A design thinking methodology is used, working through the phases of empathizing, defining, ideating, prototyping and testing the two potential designs
-
AimsVascular calcification is a common clinical complication of chronic kidney disease (CKD), atherosclerosis (AS), and diabetes, which is associated with increased cardiovascular morbidity and mortality in patients. The transdifferentiation of vascular smooth muscle cells (VSMCs) to an osteochondrogenic phenotype is a crucial step during vascular calcification. The transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα) plays an important role in regulating cell proliferation and differentiation, but whether it regulates the calcification of arteries and VSMCs remains unclear. Therefore, this study aims to understand the role of C/EBPα in the regulation of vascular calcification.Methods and ResultsBoth mRNA and protein expression levels of C/EBPα were significantly increased in calcified arteries from mice treated with a high dose of vitamin D3 (vD3). Upregulation of C/EBPα was also observed in the high phosphate- and calcium-induced VSMC calcification process. The siRNA-mediated knockdown of C/EBPα significantly attenuated VSMC calcification in vitro. Moreover, C/EBPα depletion in VSMCs significantly reduced the mRNA expression of the osteochondrogenic genes, e.g., sex-determining region Y-box 9 (Sox9). C/EBPα overexpression can induce SOX9 overexpression. Similar changes in the protein expression of SOX9 were also observed in VSMCs after C/EBPα depletion or overexpression. In addition, silencing of Sox9 expression significantly inhibited the phosphate- and calcium-induced VSMC calcification in vitro.ConclusionFindings in this study indicate that C/EBPα is a key regulator of the osteochondrogenic transdifferentiation of VSMCs and vascular calcification, which may represent a novel therapeutic target for vascular calcification.
Explore
USJ Theses and Dissertations
-
Doctorate Theses
(68)
- Faculty of Art and Humanities (13)
- Faculty of Business and Law (15)
-
Faculty of Health Sciences
(2)
- Psychology (2)
- Faculty of Religious Studies and Philosophy (5)
- Institute for Data Engineering and Science (3)
-
Institute of Science and Environment
(10)
- Science (10)
-
School of Education
(20)
- Education (20)
-
Master Dissertations
(1,155)
-
Faculty of Arts and Humanities
(122)
- Architecture (8)
- Choral Conducting (10)
- Communication and Media (43)
- Design (25)
- History and Heritage Studies (28)
- Information System (3)
- Lusophone Studies in Linguistics and Literature (8)
- Faculty of Business and Law (522)
-
Faculty of Health Sciences
(215)
- Counselling and Psychotherapy (169)
- Organisational Psychology (25)
- Social Work (20)
-
Faculty of Religious Studies and Philosophy
(26)
- Philosophy (14)
- Religious Studies (12)
- Institute of Science and Environment (28)
-
School of Education
(245)
- Education (245)
-
Faculty of Arts and Humanities
(122)
Academic Units
- Domingos Lam Centre for Research in Education (1)
-
Faculty of Arts and Humanities
(263)
- Adérito Marcos (9)
- Álvaro Barbosa (32)
- Carlos Caires (15)
- Daniel Farinha (2)
- Denis Zuev (4)
- Filipa Martins de Abreu (11)
- Filipa Simões (2)
- Filipe Afonso (12)
- Francisco Vizeu Pinheiro (10)
- Gérald Estadieu (21)
- José Simões (41)
- Nuno Rocha (2)
- Nuno Soares (44)
- Olga Ng Ka Man, Sandra (7)
- Priscilla Roberts (4)
- Tania Marques (2)
-
Faculty of Business and Law
(212)
- Alessandro Lampo (21)
- Alexandre Lobo (92)
- Angelo Rafael (3)
- Douty Diakite (15)
- Emil Marques (2)
- Florence Lei (15)
- Ivan Arraut (17)
- Jenny Phillips (14)
- Sergio Gomes (2)
- Silva, Susana C. (4)
-
Faculty of Health Sciences
(40)
- Angus Kuok (17)
- Cynthia Leong (1)
- Helen Liu (1)
- Maria Rita Silva (1)
- Vitor Santos Teixeira (10)
-
Faculty of Religious Studies and Philosophy
(95)
- Andrew Leong (6)
- Cyril Law (11)
- Edmond Eh (6)
- Fausto Gomez (1)
- Franz Gassner (10)
- Jaroslaw Duraj (9)
- Judette Gallares (3)
- Stephen Morgan (18)
- Thomas Cai (6)
-
Institute for Data Engineering and Sciences
(29)
- George Du Wencai (23)
- Liang Shengbin (9)
-
Institute of Science and Environment
(128)
- Ágata Alveirinho Dias (42)
- Chan Shek Kiu (8)
- David Gonçalves (28)
- Karen Tagulao (17)
- Raquel Vasconcelos (11)
- Sara Cardoso (7)
- Shirley Siu (9)
- Thomas Lei (8)
- Wenhong Qiu (1)
-
Library
(3)
- Emily Chan (3)
-
Macau Ricci Institute
(17)
- Jaroslaw Duraj (4)
- Stephen Rothlin (13)
-
School of Education
(194)
- Elisa Monteiro (7)
- Hao Wu (5)
- Isabel Tchiang (2)
- Keith Morrison (91)
- Kiiko Ikegami (3)
- Miranda Chi Kuan Mak (11)
- Mo Chen (3)
- Rochelle Ge (19)
- Susannah Sun (6)
Resource type
- Blog Post (3)
- Book (67)
- Book Section (128)
- Conference Paper (139)
- Document (4)
- Encyclopedia Article (1)
- Film (1)
- Journal Article (435)
- Magazine Article (19)
- Manuscript (1)
- Newspaper Article (34)
- Preprint (4)
- Presentation (64)
- Radio Broadcast (5)
- Report (62)
- Thesis (1,220)
- TV Broadcast (1)
- Web Page (2)
United Nations SDGs
- 01 - No Poverty (1)
- 02 - Zero Hunger (1)
- 03 - Good Health and Well-being (33)
- 04 - Quality Education (17)
- 05 - Gender Equality (1)
- 07 - Affordable and Clean Energy (3)
- 08 - Decent Work and Economic Growth (6)
- 09 - Industry, Innovation and Infrastructure (26)
- 10 - Reduced Inequalities (1)
- 11 - Sustainable Cities and Communities (11)
- 12 - Responsable Consumption and Production (6)
- 13 - Climate Action (8)
- 14 - Life Below Water (19)
- 15 - Life on Land (4)
- 16 - Peace, Justice and Strong Institutions (2)
- 17 - Partnerships for the Goals (1)
Cooperation
Student Research and Output
-
Faculty of Business and Law
(5)
- Neto, Andreia (1)
-
School of Education
(4)
- Áine Ní Bhroin (1)
- Emily Chan (3)
Publication year
- Between 1900 and 1999 (12)
-
Between 2000 and 2024
(2,163)
- Between 2000 and 2009 (155)
- Between 2010 and 2019 (963)
- Between 2020 and 2024 (1,045)
- Unknown (15)