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As societies globalize, mastery of a second or multiple languages has become an important index to enhance interaction in the society. In that English is a is a widely used medium of communication globally for engagement in international business, commerce, science, technology and governance, the benefits of an efficacious English language teaching force to facilitate the English acquisition process of students in classrooms around the world is highly valued. For the purpose of this study, the English language teacher efficacy instrument (ELTEI) was adapted to the local context to measure the professional efficacy of the English as a foreign language (EFL) teacher participants. The objective of the research was to investigate the degree of relationship between antecedent conditions and specific teacher efficacy in Macao. A mixed-method approach in a sequential phase design was adopted to explore the efficacy of English language teachers serving Chinese medium schools in a non-English speaking region in Asia. Phase-one employed a qualitative approach to contextualize the measurement instrument and to ascertain important characteristics of the target population. Phase-two ensured a quantitative approach to yield understanding regarding the influence of key antecedent conditions on the efficacy of English language teachers in Macao. As evidenced through multiple linear regressions and structural equation modeling, openness, neuroticism, and perceived school support were significant predictors for teacher’s self-efficacy in English teaching. Recommendations for the school management to enhance and sustain the efficacy of EFL teachers in Macao were discussed