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The marine medaka is emerging as a potential behavioral model organism for ocean studies, namely on marine ecotoxicology. However, not much is known on the behavior of the species and behavioral assays lack standardization. This study assesses the marine medaka as a potential model for chemical communication. We investigated how short exposure to visual and chemical cues mediated the stress response to social isolation with the light/dark preference test (LDPT) and the open field test (OFT). After a 5-day isolation period, and 1 h before testing, isolated fish were randomly assigned to one of four groups: (1) placed in visual contact with conspecifics; (2) exposed to a flow of holding water from a group of conspecifics; (3) exposed to both visual and chemical cues from conspecifics; or (4) not exposed to any stimuli (controls). During the LDPT, the distance traveled and transitions between zones were more pronounced in animals exposed to the conspecific's chemical stimuli. The time spent in each area did not differ between the groups, but a clear preference for the bright area in all animals indicates robust phototaxis. During the OFT, animals exposed only to chemical cues initially traveled more than those exposed to visual or both stimuli, and displayed lower thigmotaxis. Taken together, results show that chemical cues play a significant role in exploratory behavior in this species and confirm the LDPT and OFT as suitable tests for investigating chemical communication in this species.

The investigation of pharmaceuticals as emerging contaminants in marine biota has been insufficient. In this study, we examined the presence of 51 pharmaceuticals in edible oysters along the coasts of the East and South China Seas. Only nine pharmaceuticals were detected. The mean concentrations of all measured pharmaceuticals in oysters per site ranged from 0.804 to 15.1 ng g–1 of dry weight, with antihistamines being the most common. Brompheniramine and promethazine were identified in biota samples for the first time. Although no significant health risks to humans were identified through consumption of oysters, 100–1000 times higher health risks were observed for wildlife like water birds, seasnails, and starfishes. Specifically, sea snails that primarily feed on oysters were found to be at risk of exposure to ciprofloxacin, brompheniramine, and promethazine. These high risks could be attributed to the monotonous diet habits and relatively limited food sources of these organisms. Furthermore, taking chirality into consideration, chlorpheniramine in the oysters was enriched by the S-enantiomer, with a relative potency 1.1–1.3 times higher when chlorpheniramine was considered as a racemate. Overall, this study highlights the prevalence of antihistamines in seafood and underscores the importance of studying enantioselectivities of pharmaceuticals in health risk assessments.

<jats:p>Rapid urbanization and changing climatic procedures can activate the present surface urban heat island (SUHI) effect. An SUHI was considered by temperature alterations among urban and rural surroundings. The urban zones were frequently warmer than the rural regions because of population pressure, urbanization, vegetation insufficiency, industrialization, and transportation systems. This investigation analyses the Surface-UHI (SUHI) influence in Kolkata Municipal Corporation (KMC), India. Growing land surface temperature (LST) may cause an SUHI and impact ecological conditions in urban regions. The urban thermal field variation index (UTFVI) served as a qualitative and quantitative barrier to the SUHI susceptibility. The maximum likelihood approach was used in conjunction with supervised classification techniques to identify variations in land use and land cover (LULC) over a chosen year. The outcomes designated a reduction of around 1354.86 Ha, 653.31 Ha, 2286.9 Ha, and 434.16 Ha for vegetation, bare land, grassland, and water bodies, correspondingly. Temporarily, from the years 1991–2021, the built-up area increased by 4729.23 Ha. The highest LST increased by around 7.72 °C, while the lowest LST increased by around 5.81 °C from 1991 to 2021. The vegetation index and LST showed a negative link, according to the correlation analyses; however, the built-up index showed an experimentally measured positive correlation. This inquiry will compel the administration, urban planners, and stakeholders to observe humanistic activities and thus confirm sustainable urban expansion.</jats:p>

Bridging theory and practice, the up-to-date evidence from these proceedings marks an important contribution to the advancement of children and youth health and well-being professions in the issues of technology, health, stress, inclusion, and resilience. The empirical research reported here examines the perceptions of parents, social workers, counselors, and other helping professionals concerning their awareness of child protection and parent-child relationships. These proceedings serve as a catalyst for action, enabling researchers and practitioners to reference and view the newest research through the lenses of diverse themes that focus on children and youth health and well-being, and to impact the younger population at micro and macro levels. This key text has several important features: 1. It emphasizes the impact of digital technology on well-being among children and young people in this digital age, and how to involve different stakeholders who can help to respond to emergent and existing challenges. 2. It introduces learning disabilities and issues in the field of mental stress and the biopsychology of developmental needs in school settings in addressing the UN Sustainable Development Goals. 3. It advances health knowledge and care practice through practice-oriented research, establishing new benchmarks in health care work, identifying its possibilities and constraints. 4. It enriches knowledge in the field of safeguarding for adults, including parental involvement in identifying and responding to children and youth well-being.

A greater amount of existing literature suggests that personal electronic devices (PEDs), such as smartphones, are detrimental to individuals in different aspects; a smaller amount of existing literature looks at the positive impacts of PEDs. Also, most of the literature used a quantitative approach, whereas very few of them used qualitative and mixed methods approaches. Based on my observation and experience, and talking to some young adults, it seems that what the existing literature suggests may not be truly revealing what is actually happening nowadays. With this, the present study was conducted to answer the questions: 1) What is young adults' PED use? 2) How does PED use affect (associate with) young adults' development? The present study used explanatory sequential mixed methods research design, with quantitative survey conducted first, and then followed by qualitative interviews in which questions were developed based on the findings in the quantitative phase. A sample of 736 undergraduates from five universities in Macau (M = 21.9, SD = 4.1) participated in quantitative phase, and a subsample of 13 participants from quantitative phase participated in the qualitative phase interviews. Respondents’ scores on a self-report measure of personal electronic device (PED) use were compared sociodemographic factors (i.e., age, gender, maternal language, and type of family). Qualitative data were analysed using thematic analysis. Quantitative results showed that PED use is a continuous and integral part of young adults' daily lives in Macau. Increased internet use and specific activities correlate with developmental outcomes, but only extreme use is associated with negative outcomes. Interaction and communication with others are key to happiness, regardless of call duration. Using diverse devices relates to less smartphone addiction and more happiness and social satisfaction, but mobile phones and laptops are not linked to positive or negative outcomes. PED use itself is not harmful; it is only problematic when used excessively. Qualitative results showed that PED use is an integral part of young adults' daily lives in Macao due to the powerful characteristics of PEDs that enable various tasks (Theme 1), and the necessity of PED use across different contexts and with different people (Theme 2). PEDs are used for fundamental purposes like communication, productivity, and psychosocial needs (Theme 3), leading to both positive and negative impacts on individuals' lives (Theme 4). PED use is a spectrum, not a dichotomy, distinguished by factors like maladaptation, compulsivity, overuse, and attachment (Theme 5). This qualitative study deepens the understanding of PED use beyond the quantitative findings. By linking and integrating quantitative and qualitative data and applied the theoretical framework of the present study, an extension of the bioecological theory, cloudsystem is proposed. It is believed that the cloudsystem contributes to a better understanding of the person in this specific moment of human’s existence. Practical implications, strengths and limitations of the study, suggestions for future studies were also discussed.

The convergence of air pollution control and climate change mitigation is critical in the pursuit of sustainable development. Therefore, technological innovations are pivotal in addressing the dual challenges of air pollution and global warming. This work presents an overview of technological solutions aimed at reducing air pollution and mitigating GHG emissions. While evaluating their technological strengths and limitations in real applications, this work offers a framework to promote a transition toward blue skies and net-zero emissions. This work also identifies the main sources and negative impacts of air pollution on public health and the environment. A literature overview of published articles from 1976 to 2024 showed that integrating emission reduction technologies are vital in real-word applications. More than 98% of the SO2 in the flue gas can be removed using cutting-edge desulfurization technology. SO2 is eliminated from the environment either unaltered or as sulfuric acid and sulfates. Meanwhile, thermal incinerators boast an impressive efficiency, capable of eliminating 99% of gaseous pollutants. Although existing pollution control technologies are promising to mitigate climate change, they still require further research, development, demonstration, and deployment to overcome barriers and achieve their potential. By examining the effectiveness of control technologies and proposing adaptable strategies, this work highlights the potential of integrating air quality improvement efforts with climate actions. Not only this addresses the global need for cleaner air, but also contributes to the overarching goal of climate stabilization. © The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences 2024.

Anticancer peptides (ACPs) are promising future therapeutics, but their experimental discovery remains time-consuming and costly. To accelerate the discovery process, we propose a computational screening workflow to identify, filter, and prioritize peptide sequences based on predicted class probability, antitumor activity, and toxicity. The workflow was applied to identify novel ACPs with potent activity against colorectal cancer from the genome sequences of Candida albicans. As a result, four candidates were identified and validated in the HCT116 colon cancer cell line. Among them, PCa1 and PCa2 emerged as the most potent, displaying IC50 values of 3.75 and 56.06 μM, respectively, and demonstrating a 4-fold selectivity for cancer cells over normal cells. In the colon xenograft nude mice model, the administration of both peptides resulted in substantial inhibition of tumor growth without causing significant adverse effects. In conclusion, this work not only contributes a proven computational workflow for ACP discovery but also introduces two peptides, PCa1 and PCa2, as promising candidates poised for further development as targeted therapies for colon cancer. The method as a web service is available at https://app.cbbio.online/acpep/home and the source code at https://github.com/cartercheong/AcPEP_classification.git.

This study sought to determine the strategy that allowed the Las Vegas Sands Corporation (LVS) to attain its leading status in the casino industry and to gain insight whether this status would continue given (i) the passing of the LVS founder, Sheldon Adelson, in January 2021, (ii)the sell-off of the company's Las Vegas properties early in 2022, and (iii) the firm's greater sensitivity to events in China caused by the company's increased reliance for most of its customers on the mainland China market. The study first identified the nature of the LVS competitive advantages when Adelson was directing the firm and then assessed whether these had been adversely impacted due to changes in the firm's markets, management or strategy. The study relied initially on the work of David Baron, Professor of Political Economy and Strategy at Stanford University who as early as 1981 advanced the view that corporate strategy needed to be divided in a Marketing Strategy (MS) and a Non-Market Strategy (NMS). The NMS component for LVS was critically important since government determined who could acquire a Macau casino concession and what level of visas would be provided to Mainland China gamblers to fill the Macau casinos. The key question became the nature of Adelson's Political Effectiveness as determined by the NMS he directed towards the China market. To resolve this issue, we adopted the Wellner & Lakotta proposal to extend Porter's Five Forces analytical framework by two additional dimensions, Government Interventors and Complementor Organizations. We concluded that it was highly likely that Goldman Sachs, the long-term financial backer of Sheldon Adelson, played a significant if not the major role in the success Adelson was able to achieve in the Greater China market.

近年來，博物館的休閒、教育、娛樂功能等日益重要，其對文化教育的貢 獻也越來越受到博物館參觀者的認可。相關的文獻大多數探討於博物館的服務 質量與參觀者參觀博物館體驗的滿意度之間的關係。目前，以參觀者的博物館 體驗如何影響他們重遊博物館的專門論述或深入研究並不多。因此，本研究的 研究目的是以博物館的體驗為中心，探討哪些因素會影響參觀者參觀博物館的 體驗，以及這些因素如何影響參觀者對博物館的重遊意願。本研究以篩選的方 式隨機抽查了 10 位參觀過博物館體驗的參觀者進行半結構式訪談(Semi- structured interview)，深入地了解受訪者的博物館體驗以及影響他們重遊博物 館的因素等問題，並以文獻及理論為基礎探討參觀者在參觀博物館過程會影響 他們的因素。採訪會在博物館附近進行，並採用深度定性訪談法(In-depth qualitative interview)，研究對象為澳門的本地參觀者。

<jats:p>To comply with the United Nations Sustainable Development Goals (UN SDGs), in particular with SDG 3, SDG 11, and SDG 13, a reliable air pollution prediction model must be developed to construct a sustainable, safe, and resilient city and mitigate climate change for a double win. Machine learning (ML) and deep learning (DL) models have been applied to datasets in Macau to predict the daily levels of roadside air pollution in the Macau peninsula, situated near the historical sites of Macau. Macau welcomed over 28 million tourists in 2023 as a popular tourism destination. Still, an accurate air quality forecast has not been in place for many years due to the lack of a reliable emission inventory. This work will develop a dependable air pollution prediction model for Macau, which is also the novelty of this study. The methods, including random forest (RF), support vector regression (SVR), artificial neural network (ANN), recurrent neural network (RNN), long short-term memory (LSTM), and gated recurrent unit (GRU), were applied and successful in the prediction of daily air pollution levels in Macau. The prediction model was trained using the air quality and meteorological data from 2013 to 2019 and validated using the data from 2020 to 2021. The model performance was evaluated based on the root mean square error (RMSE), mean absolute error (MAE), Pearson’s correlation coefficient (PCC), and Kendall’s tau coefficient (KTC). The RF model best predicted PM10, PM2.5, NO2, and CO concentrations with the highest PCC and KTC in a daily air pollution prediction. In addition, the SVR model had the best stability and repeatability compared to other models, with the lowest SD in RMSE, MAE, PCC, and KTC after five model runs. Therefore, the results of this study show that the RF model is more efficient and performs better than other models in the prediction of air pollution for the dataset of Macau.</jats:p>

<jats:p>The mass production of uniform, high-quality polymer nanofibers remains a challenge. To enhance spinning yield, a multi-string standing wave electrospinning apparatus was developed by incorporating a string array into a standing wave electrospinning device. The process parameters such as string spacing, quantity, and phase difference were optimized, and their effects on the electric field distribution within the spinning area were analyzed using electric field simulations. When the string spacing was less than 40 mm or the number of strings exceeded two, the electric field strength significantly decreased due to electric field interference. However, this interference could be effectively mitigated by setting the string standing wave phase difference to half a period. The optimal string array parameters were identified as string spacing of 40 mm, two strings, and a phase difference of half a period. Multi-string standing wave electrospinning produced fibers with diameters similar to those obtained with single-string standing wave electrospinning (178 ± 72 nm vs. 173 ± 48 nm), but the yield increased by 88.7%, reaching 2.17 g/h, thereby demonstrating the potential for the large-scale production of nanofibers. This work further refined the standing wave electrospinning process and provided valuable insights for optimizing wire-type electrospinning processes.</jats:p>

Social Media Influencer (SMI) marketing represents a contemporary addition to the arsenal of digital advertising tools. Digital Content Creators are individuals who regularly share a variety of content, including visuals, audio recordings, and updates, across multiple social media platforms to shape consumers' perceptions of a brand and its products. The focus of this study is to examine how the credibility aspects of social media influencers (expertise, attractiveness, and trustworthiness) influence purchase intention and brand intimacy while also considering the mediating role of consumer engagement. This study used a quantitative, cross-sectional design with convenience sampling targeting social media-active individuals. Data were collected via a questionnaire distributed through email and social media, selecting participants who followed influencers. To gather data, 250 participants were engaged in an online questionnaire distributed via Google Forms. The findings indicate that the credibility dimensions of SMIs, particularly their attractiveness and trustworthiness, positively influence brand intimacy and purchase intention. Furthermore, consumer engagement serves as a critical mediator, connecting the authenticity of social media influencers with purchase intention and brand intimacy. In line with these results, it becomes evident that consumer engagement indirectly influences influencer credibility (trustworthiness and attractiveness), purchase intention, and brand intimacy. Notably, expertise does not exert any discernible impact on either brand intimacy or purchase intention. This study's outcomes provide valuable insights for marketing managers, underscoring the significance of partnering with influencers who possess a high level of trust within their respective marketing niches.

Traditional healthcare typically focuses on the treatment of illness and medical consultations (TAHIRU, 2021). However, new generations of health centers are moving beyond this traditional model. Nowadays, it has shifted to prioritizing preventive care, such as wellness programs, fitness classes, mental health support services and leisure activities to promote healthy lifestyles (Marizahn, 2020). Hence, this research focuses on exploring how an integrated health center approach could address the mental health challenges of youth in Macao.

In the first half of the 20th century, Macao’s three traditional handicraft industries were: making matches, firecrackers, and incense, and these three became important pillars of Macao's economy. These industries were supported by four other industries, namely: shipbuilding, wine, printing and the clothing that are integral to understanding the history of Macao. The purpose of this research has been to document the importance of Macao's seven traditional industries, in particular the firecracker factories with special reference to the Yick Loong factory. This dissertation makes a significance contribution to the subject of the historical development of Macao’s traditional handicraft industries in reviewing each of the traditional industries and in particular detailing the Yick Loong factories operations and the understanding of the local Macao people to the past importance of this operation. These industries need to be discussed so that society can have a deeper understanding of the importance of them, as up to now they have been little explored. So, by visiting the location of the Yick Loong Firecracker Factory, gathering knowledge, and conducting in-depth research and in books and through a survey about the Macao firecracker business, the author has been able to show that there appears to be limited understanding of the significance of the firecracker industry in Macao. Though, people most recall the Yick Loong factory’s name when prompted about naming a firecracker factory in Macao and associate firecrackers with the Lunar New Year celebrations. However, they seem to have limited understanding of the significance of the firecrackers to Macao, except for childhood memories of them being released.

The purpose of this study was to investigate the impact of parents engaging in dialogic reading with their children while reading picture books on children's emotional understanding and parent-child relationships. The study also attempted to investigate the potential of picture books as useful instruments for parent-child communication, fostering meaningful parent-child connection and augmenting children's emotional comprehension. The study lasted for 11 weeks. The initial three weeks were focused on a parent-child reading session specifically designed for mothers, and the next eight weeks consisted of a picture book reading program in the participants' homes. Convenience sampling was employed to choose 11 families for participation in the study. Throughout the 8-week reading program, families actively participated in parent-child picture book reading sessions at home, ensuring a minimum frequency of once per week. The study used a combination of multiple case studies and a case study-mixed methods design. The data collection process involved gathering quantitative data through various means, including administering primary background surveys, utilizing the Child-Parent Relationship Scale (CPRS), and employing the Children’s Emotional Development Scale. The qualitative data consisted of interviews conducted before the intervention and records documenting parental reading observations. The analysis methodologies used in this study encompassed thematic and content analysis, which involved combining qualitative and quantitative findings to facilitate comparison. The quantitative data analysis of the Child Emotional Development Scale revealed notable disparities in emotional cognition, comprehension, expression, and overall emotional competence scores between the initial and final examinations. Although the CPRS results did not reveal any notable disparities in family intimacy and conflict; it is worth noting that seven families had higher post-test scores in family intimacy, indicating that mothers perceived an improved level of closeness with their children. Qualitative data analysis revealed that through shared reading of picture books on various emotional themes, children learned more emotional vocabulary and engaged in deeper parent-child conversations beyond daily interactions. This increased children's opportunities for emotional expression and helped mothers better understand their children's emotional needs, reflect on their parenting skills, and foster parent-child interaction and communication. In conclusion, this study demonstrated the significant impact of engaging in dialogic parent-child picture book reading on emotional understanding in preschool children. Furthermore, it is believed to be a valuable parent-child interaction strategy for dual-income families in Macau, enhancing parent-child relationships.

As cities continue to grow at an unprecedented rate, the need for efficient land use becomes even more critical. Mixed Use Architecture is essential for modern cities because of its efficiency in using land that is prevalent in the rapid urbanization we are facing today. Mixed-use development offers numerous advantages for communities and serves as a crucial approach in attaining sustainable ecosystems (Woo and Cho, 2018). Land scarcity in Macau has made mixed-use architecture essential to city expansion. Mixed-use developments in Macau typically consist of combination of housing and commercial towers, casino and hotel complexes and office buildings. This has improved land use in the city. However, these developments, however, unappetizing living conditions resulting sick building syndrome to its residents. The research question identified and addressed in this study is: How can Mixed Use Architecture respond to the underlying problems Urbanisation has brought? Based on this question, this dissertation develops a new type prototype for mixed use architecture that to resolve the issues prevalent in the current mixed use architecture models using Macau as context for this prototype. This study challenges traditional architecture and uses innovative approaches stemming from biophilic strategies and industry leading green technologies that improve quality of life and the environment. This study proposes a novel solution to urbanization's problems such Sick Building Syndrome, high population density, and land scarcity. This dissertation suggests a space-efficient architecture to meet the needs of rising populations and land scarcity while prioritizing resident well-being.

In today's rapidly changing educational landscape, parents and children demand personalised, innovative, and engaging learning experiences beyond the standard curriculum. Modern education places a premium on igniting curiosity, encouraging critical thinking, and cultivating creativity. Collaborative learning between parents and children is critical for improving academic performance and strengthening relationships. This article discusses the "Yay Island" platform's game-based technique, which combines Mandarin Chinese and English in a multicultural and multilingual setting. Initial study shows that digital technologies dramatically increase children's motivation and interest when paired with peer and parent participation and game-based teaching, resulting in a pleasant learning environment. Further research demonstrates that collaborative and game-based learning and teaching improves motivation, respects individual differences, and strengthens parent-child connections. As a game, "Yay Island" uses integrated learning, child psychology concepts, modern educational methodologies, and user-centred design. It seeks to develop a collaborative learning environment and encourage growth in children, parents, and educators. The game emphasises knowledge, personal discovery, and innovation, laying the groundwork for children's growth and future competition. Through constant research and optimisation, "Yay Island" solves digital transformation concerns in education by providing personalised, efficient, and entertaining learning experiences.

Macau, as a densely populated city, has been facing a prominent challenge in fulfilling the rapidly growing demand for land due to its small geographical size. The limited availability of land exacerbates the conflict between urban development needs and land supply, leading to an imbalance in land resource allocation. This scarcity of land not only hinders the city's ability to meet its growing population's housing needs but also contributes to a lack of social space. The absence of adequate outdoor gathering areas and communal spaces has resulted in the fragmentation of communities and a fading sense of community in the society of Macau. As the urban environment undergoes relentless development, the social fabric of Macau is undergoing a transformation. Communities are becoming fragmented into smaller groups, and chance encounters and serendipitous social interactions are being neglected or excluded. Social events primarily take place within dedicated indoor spaces that cater to groups, further isolating different segments of the population due to the limited and subpar outdoor gathering space available. This dissertation aims to examine the possibility of developing a new housing prototype that could provoke connections between segregated communities. By introducing a combination of communal spaces and vertical circulation spaces, the design seeks to create opportunities for social interaction and the revitalisation of community bonds that could eventually fit into a hyperdense city. To achieve this, the dissertation will begin with a comprehensive site analysis of the site, considering both the physical constraints and the potential benefits for social space creation. Furthermore, the study will draw insights from relevant literature and architectural projects that have addressed relevant challenges, exploring effective strategies for fostering community engagement and creating inclusive social spaces. The design process will emphasise the integration of communal spaces that encourage spontaneous interactions and vertical circulation spaces that facilitate movement and connectivity between different community segments.

This project represents a comprehensive study of an interactive picture book employing augmented reality (AR) technology, focusing on the narratives of the A-Ma Temple and Nezha Temple in Macau. The target audience comprises children aged 6-9 years to enhance their concentration on aesthetic development and deepen their understanding of Macau's historical and cultural heritage. The study resulted in the creating of a picture book that integrates an interactive AR experience, resulting in highly satisfactory user feedback. The findings suggest the potential for further development of interactive picture books as a valuable medium for disseminating Macanese culture. Future efforts should prioritise continuous attention to user feedback and the AR technology's stability to ensure the work's long-term effectiveness and impact.