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Nessa noite decidiram hospedar-se num motel pois queriam acordar às 3.45 para ver o primeiro sol das Américas na Ponta de Seixas, João Pessoa, Paraíba. Subiram à torre do Nazareno às 4.45 e, quando já pensavam que as nuvens não iam deixar assistir ao nascer de mais um dia aprazível, eis que ele, o senhor rei dos dias, surge do mar. Enquanto os olhos brilhavam ao sol, lembrou-se que Chico César era dali perto, do interior da Paraíba, para as bandas de Campina Grande. Recordou que a primeira vez que tentou olhá-lo nos olhos percebeu que ele estava envolvido numa […]
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AimsVascular calcification is a common clinical complication of chronic kidney disease (CKD), atherosclerosis (AS), and diabetes, which is associated with increased cardiovascular morbidity and mortality in patients. The transdifferentiation of vascular smooth muscle cells (VSMCs) to an osteochondrogenic phenotype is a crucial step during vascular calcification. The transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα) plays an important role in regulating cell proliferation and differentiation, but whether it regulates the calcification of arteries and VSMCs remains unclear. Therefore, this study aims to understand the role of C/EBPα in the regulation of vascular calcification.Methods and ResultsBoth mRNA and protein expression levels of C/EBPα were significantly increased in calcified arteries from mice treated with a high dose of vitamin D3 (vD3). Upregulation of C/EBPα was also observed in the high phosphate- and calcium-induced VSMC calcification process. The siRNA-mediated knockdown of C/EBPα significantly attenuated VSMC calcification in vitro. Moreover, C/EBPα depletion in VSMCs significantly reduced the mRNA expression of the osteochondrogenic genes, e.g., sex-determining region Y-box 9 (Sox9). C/EBPα overexpression can induce SOX9 overexpression. Similar changes in the protein expression of SOX9 were also observed in VSMCs after C/EBPα depletion or overexpression. In addition, silencing of Sox9 expression significantly inhibited the phosphate- and calcium-induced VSMC calcification in vitro.ConclusionFindings in this study indicate that C/EBPα is a key regulator of the osteochondrogenic transdifferentiation of VSMCs and vascular calcification, which may represent a novel therapeutic target for vascular calcification.
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"As an atheistic religious tradition, Buddhism conventionally stands in opposition to Christianity, and any bridge between them is considered to be riddled with contradictory beliefs on God the creator, salvific power and the afterlife. But what if a Buddhist could also be a Classical Theist? Showing how the various contradictions are not as fundamental as commonly thought, Tyler Dalton McNabb and Erik Baldwin challenge existing assumptions and argue that Classical Theism is, in fact, compatible with Buddhism. They draw parallels between the metaphysical doctrines of both traditions, synthesize their ethical and soteriological commitments and demonstrate that the Theist can interpret the Buddhist's religious experiences, specifically those of emptiness, as veridical, without denying any core doctrine of Classical Theism. By establishing that a synthesis of the two traditions is plausible, this book provides a bold, fresh perspective on the philosophy of religion and reinvigorates philosophical debates between Buddhism and Christianity"--
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In this essay we argue that, based on current scientific data, the most prudential course of future actions that an American conservative can take, is one that assumes what we call climate change alarmism. In order to establish this thesis, we first provide a basic overview of the relevant climate change science, as well as give an analysis of the alarmist and lukewarming dialectic (the two primary interpretations of the data). We then move to develop our environmental wager. Finally, following Roger Scruton, we end this work by proposing what sort of policies conservatives should endorse going further.
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Launonen and Mullins argue that if Classical Theism is true, human cognition is likely not theism-tracking, at least, given what we know from cognitive science of religion. In this essay, we develop a model for how classical theists can make sense of the findings from cognitive science, without abandoning their Classical Theist commitments. We also provide an argument for how our model aligns well with the Christian doctrine of general revelation.
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Despite the prevalence of aesthetic education as one of the main developmental objectives in curricular worldwide, the mainstream philosophical discourse on its definition is predominately framed by western philosophy due to a paucity of cross-cultural studies on the subject. The article aims to achieve a contemporary understanding of aesthetic education from both the Chinese and Western aesthetic perspectives. Through the lens of postmodernism, the relationship between Daoist aesthetics and the western postmodern aesthetic perspectives, particularly the Deleuzian concept of rhizome, is identified. Both aesthetic perspectives concern de-authorship and promote self-consciousness/self-awareness. The study reconceptualises the functions of aesthetic education with the Chinese aesthetic philosophy that promotes the nurture of better people through benevolence.
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Molecular Chinese Medicine (MCM) is a recent method of manufacturing and dosing prescriptions that brings several advantages when compared with Traditional Chinese Medicine (TCM). For instance, MCM is highly dissoluble, tastes better than the usual decoction, and the active principles are easily absorbed. Also, the manufacturing process is subject to better quality control. In spite of these benefits, consumers' intentions remain unclear due to the novelty of this technique. Therefore, an assessment of individuals' perceptions is relevant since molecular medicine is redefining how scientists understand and treat diseases, and it can be considered a medical innovation. To fill the research gap, the Value-based Acceptance Model (VAM) (Kim et al., 2007) is used to assess the individuals' perceptions of value and intention to accept MCM. Data from a sample of Macau residents are analyzed by means of structural equation modeling (SmartPLS). The results support the use of the model in our context, thus extending the applicability of the VAM to other settings. Except for 'technicality', the constructs of 'usefulness', 'enjoyment', and 'perceived fee' had a significant impact on the overall 'perceived value' of MCM, and in turn on the behavioral intention to use the innovation. To facilitate the diffusion of this dosage method in the marketplace, it is suggested that communications strategies consider the proposed sources of value when promoting MCM. To further explain the adoption process, it is recommended to include additional factors that may affect consumers' intention to adopt the innovation and extend the analysis to the actual usage.
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The global living standard improved significantly in the last decades and China moved 800 million people out of poverty since 1980. However, production and consumption in their current forms are unsustainable in matters of resource and energy use and involved emissions with their significant ecological impact. The global human community committed itself in the COP21 Agreement of Paris 2015 to reduce Green House Gas (GHG) emissions based on National Determined Contributions (NDCs) in order to limit the increase of global average temperature below 2°C or better 1.5°C above pre industrial levels. This commitment entails a comprehensive transformation of the current social and economic system in view of decoupling economic growth from both resource extraction and GHG emissions, in view of fostering a resource sensitive and CO2 neutral Circular Economy (CE) based on Sustainable Development (SD). China submitted its first Intended Nationally Determined Contributions (INDCs) in 2015 with policies and measures affecting 15 major areas. In 2020, President Xi Jinping announced the commitment to peak China’s carbon dioxide emissions before 2030 and achieving carbon neutrality before 2060. Proper and Integrated Resource and Waste Management is central on the way to achieve the transformation into a CE. The State Council of the People’s Republic of China (PRC) released its plan “生活垃圾分类制度实施方案” to promote source separation of household waste on March 30, 2017 aiming at the recycling rate for household waste to reach 35% by 2020 for the selected cities. The first China’s Mandatory Waste Source Separation Law “廣州 市生活垃圾分類管理條例” was enforced by the city of Guangzhou on July 1st, 2018. One of the key strategic plans in China is the development of the Greater Bay Area (GBA) with its comprehensive development plan released on February 18, 2019. Following the INDCs by China, parts of the GBA Development Plan emphasize that the development of the CE systems and the implementation of extended producer responsibility (EPR), are effective principles to provide financial incentives in view of reducing embedded emissions in material and processes. The present research studied, analysed, and compared the MSW treatment strategies, rules, regulations, and retrievable data, which lead to MSW source separation and the reverse logistic of separated waste among 4 selected cities Guangzhou, Zhuhai, and the 2 S.A.R.s of Hong Kong and Macao. The experience and comparison from Guangzhou and Hong Kong revealed that a Top-down approach in environmental policy decision making is more efficient and is able to implement necessary policies faster. However, the experiences from Guangzhou and Zhuhai indicate, that also a more participatory implementation process is crucial, as it enables the involved stakeholders to express their experiences and opinions properly, which can lead to a higher level of policy feasibility and acceptance and a smoother operation accompanied with a higher effectiveness. For the two SARs, to achieve the objective to increase the recycling rate, the local Government must seek approval from China’s Central Government to allow locally generated recyclable material, in their original form, to enter mainland China for further treatment and to be turned into secondary raw material. Without such a proper support by a reverse resource logistic from the mainland, the CE schemes, such as the Mandatory Waste Source Separation, Producer Responsibility Scheme (PRS), Waste Charging Scheme, are not able to be implemented effectively. The current approach of the Local Government purchasing of recycling and exportation services of recyclable materials from private companies, and the sole reliance on existing market forces to handle, process, and export recyclable material out of the S.A.R.s cannot ensure a reliable and continuous operation in view of mitigating involved emissions. By way of a comparative analyses, the present investigation works out and distils suggestions for best practices of implementing the CE to comply with targets of emission reductions
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Various materials, objects, and sensors have been explored earlier for creating tangible user interfaces (TUIs). However, there is little work on 3D-printed TUIs based on visual markers for smartphone-based extended reality (XR) experiences. The combination of visual markers and smartphones results in cheap, accessible XR systems within reach of many people. Combined with 3D printing, it could foster do-it-yourself (DIY) projects for XR experiences, which may further expand and open-up possibilities for accessible and tangible interaction. This work explores the design space of modular 3D-printed tangibles for smartphone-based XR. The authors report the design exploration process, provide several interactive 3D-printed markers, and reflect on the resulting possibilities.
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