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The pathophysiological mechanisms of arterial hypertension during hemodialysis (HD) in patients with end-stage renal disease (ESRD) are still poorly understood. The aim of this study is to investigate physiological, cardiovascular and neuroendocrine changes in patients with ESRD and its correlation with changes in blood pressure (BP) during the HD session. The present study included 21 patients with ESRD undergoing chronic HD treatment. Group A (study) consisted of patients who had BP increase and group B (control) consisted of those who had BP reduction during HD session. Echocardiograms were performed during the HD session to evaluate cardiac output (CO) and systemic vascular resistance (SVR). Before and after the HD session, blood samples were collected to measure brain natriuretic peptide (BNP), catecholamines, endothelin-1 (ET-1), nitric oxide (NO), electrolytes, hematocrit, albumin and nitrogen substances. The mean age of the studied patients was 43±4.9 years, and 54.6% were males. SVR significantly increased in group A (P<0.001). There were no differences in the values of BNP, NO, adrenalin, dopamin and noradrenalin, before and after dialysis, between the two groups. The mean value of ET-1, post HD, was 25.9 pg ml−1 in group A and 13.3 pg ml−1 in group B (P=<0.001). Patients with ESRD showed different hemodynamic patterns during the HD session, with significant BP increase in group A, caused by an increase in SVR possibly due to endothelial dysfunction, evidenced by an increase in serum ET-1 levels.

This paper presents an algorithm that applies metrics derived from automatic QRS detection and segmentation in electrocardiogram signals for analyzing Heart Rate Variability to study the evolution of metrics in the frequency domain of a clinical procedure. The analysis was performed on three sets of elderly people, who are categorized according to frailty phenotype. The first set was comprised of frail elderly, the second pre-frail elderly, and the third robust elderly. Investigators from many disciplines have been encouraged to contribute to the understanding of molecular and physiological changes in multiple systems that may increase the vulnerability of frail elderly. In this work, the frailty phenotype can be characterized by unintentional weight loss, as self-reported, fatigue assessed by self-report, grip strength (measured directly), physical activity level assessed by self-report and gait speed (measured). The results obtained demonstrate the existence of significant differences between Heart Rate Variability metrics for the three groups, especially considering a higher preponderance for sympathetic nervous system for the group of robust patients in response to postural maneuver.

The visual analysis of cardiotocographic examinations is a very subjective process. The accurate detection and segmentation of the fetal heart rate (FHR) features and their correlation with the uterine contractions in time allow a better diagnostic and the possibility of anticipation of many problems related to fetal distress. This paper presents a computerized diagnostic aid system based on digital signal processing techniques to detect and segment changes in the FHR and the uterine tone signals automatically. After a pre-processing phase, the FHR baseline detection is calculated. An auxiliary signal called detection line is proposed to support the detection and segmentation processes. Then, the Hilbert transform is used with an adaptive threshold for identifying fiducial points on the fetal and maternal signals. For an antepartum (before labor) database, the positive predictivity value (PPV) is 96.80% for the FHR decelerations, and 96.18% for the FHR accelerations. For an intrapartum (during labor) database, the PPV found was 91.31% for the uterine contractions, 94.01% for the FHR decelerations, and 100% for the FHR accelerations. For the whole set of exams, PPV and SE were both 100% for the identification of FHR DIP II and prolonged decelerations.

It is known that the probability is not a conserved quantity in the stock market, given the fact that it corresponds to an open system. In this paper we analyze the flow of probability in this system by expressing the ideal Black-Scholes equation in the Hamiltonian form. We then analyze how the non-conservation of probability affects the stability of the prices of the Stocks. Finally, we find the conditions under which the probability might be conserved in the market, challenging in this way the non-Hermitian nature of the Black-Scholes Hamiltonian.

It is plausible to assume that the component waves in ECG signals constitute a unique human characteristic because morphology and amplitudes of recorded beats are governed by multiple individual factors. According to the best of our knowledge, the issue of automatically classifying different ’identities’ of QRS morphology has not been explored within the literature. This work proposes five alternative mathematical models for representing different QRS morphologies providing the extraction of a set of features related to QRS shape. The technique incorporates mechanisms of combining the mathematical functions Gaussian, Mexican-Hat and Rayleigh probability density function and also a mechanism for clipping the waveform of those functions. The searching for the optimal parameters which minimize the normalized RMS error between each mathematical model and a given QRS search window enables to find an optimal model. Such modeling behaves as a robust alternative for delineating heartbeats, classifying beat morphologies, detecting subtle and anomalous changes, compression of QRS complex windows among others. The validation process evaluates the ability of each model to represent different QRS morphology classes within 159 full ECG signal records from QT database and 584 QRS search windows from MIT-BIH Arrhythmia database. From the experimental results, we rank the winning rates for which each mathematical model best models and also discriminates the most predominant QRS morphologies Rs, rS, RS, qR, qRs, R, rR’s and QS. Furthermore, the average time errors computed for QRS onset and offset locations when using the corresponding winner mathematical models for delineation purposes were, respectively, 12.87±8.5 ms and 1.47±10.06 ms.

The use of learning analytics (LA) in real-world educational applications is growing very fast as academic institutions realize the positive potential that is possible if LA is integrated in decision making. Education in schools on public health need to evolve in response to the new knowledge and th...

Crowdsensing exploits the sensing abilities offered by smart phones and users' mobility. Users can mutually help each other as a community with the aid of crowdsensing. The potential of crowdsensing has yet to be fully realized for improving public health. A protocol based on gamification to encoura...

The identification of barriers for e-commerce to thrive in specific countries is a topic of great interest. This work proposes two models to study the barriers to B2C e-commerce adoption in Portugal, highlighting obstacles less exploited by previous research: the impact of offline shopping pleasure and the influence of the distance to shopping malls on online shopping intent. An online survey was conducted based on different constructs. A multivariate OLS hierarchical regression was used to analyse the proposed models regarding the intention to buy online and the number of online purchases. The results revealed that customer satisfaction is a strong predictor of intent to buy online and that perceived product risk remains a barrier to e-commerce. Consumers living in high urbanised areas have more propensity to buy online. Helpful information is provided regarding the impact of context, culture, product, and individual barriers, showing that multichannel strategies are best suited for success.

The spontaneous symmetry breaking phenomena applied to Quantum Finance considers that the martingale state in the stock market corresponds to a ground (vacuum) state if we express the financial equations in the Hamiltonian form. The original analysis for this phenomena completely ignores the kinetic terms in the neighborhood of the minimal of the potential terms. This is correct in most of the cases. However, when we deal with the martingale condition, it comes out that the kinetic terms can also behave as potential terms and then reproduce a shift on the effective location of the vacuum (martingale). In this paper, we analyze the effective symmetry breaking patterns and the connected vacuum degeneracy for these special circumstances. Within the same scenario, we analyze the connection between the flow of information and the multiplicity of martingale states, providing in this way powerful tools for analyzing the dynamic of the stock markets.

Background and objective Intrauterine Growth Restriction (IUGR) is a condition in which a fetus does not grow to the expected weight during pregnancy. There are several well documented causes in the literature for this issue, such as maternal disorder, and genetic influences. Nevertheless, besides the risk during pregnancy and labour periods, in a long term perspective, the impact of IUGR condition during the child development is an area of research itself. The main objective of this work is to propose a machine learning solution to identify the most significant features of importance based on physiological, clinical or socioeconomic factors correlated with previous IUGR condition after 10 years of birth. Methods In this work, 41 IUGR (18 male) and 34 Non-IUGR (22 male) children were followed up 9 years after the birth, in average (9.1786 ± 0.6784 years old). A group of machine learning algorithms is proposed to classify children previously identified as born under IUGR condition based on 24-hours monitoring of ECG (Holter) and blood pressure (ABPM), and other clinical and socioeconomic attributes. In additional, an algorithm of relevance determination based on the classifier is also proposed, to determine the level of importance of the considered features. Results The proposed classification solution achieved accuracy up to 94.73%, and better performance than seven state-of-the-art machine learning algorithms. Also, relevant latent factors related to HRV and BP monitoring are proposed, such as: day-time heart rate (day-time HR), day-night systolic blood pressure (day-night SBP), 24-hour standard deviation (SD) of SBP, dropped, morning cortisol creatinine, 24-hour mean of SDs of all NN intervals for each 5 minutes segment (24-hour SDNNi), among others. Conclusion With outstanding accuracy of our proposed solutions, the classification system and the indication of relevant attributes may support medical teams on the clinical monitoring of IUGR children during their childhood development.

Monitoring signals such as fetal heart rate (FHR) are important indicators of fetal well-being. Computer-assisted analysis of FHR patterns has been successfully used as a decision support tool. However, the absence of a gold standard for the building blocks decision-making in the systems design process impairs the development of new solutions. Here we propose a prognostic model based on advanced signal processing techniques and machine learning algorithms for the fetal state assessment within a comprehensive evaluation process. Feature-engineering-based and time-series-based machine learning classifiers were modeled into three data segmentation schemas for CTU-UHB, HUFA, and DB-TRIUM datasets and the generalization performance was assessed by a two-way cross-dataset evaluation. It has been shown that the feature-based algorithms outperformed the time-series ones on data-limited scenarios. The Support Vector Machines (SVM) obtained the best results on the datasets individually: specificity (85.6% ) and sensitivity (67.5%). On the other hand, the most effective generalization results were achieved by the Multi-layer perceptron (MLP) with a specificity of 71.6% and sensitivity of 61.7%. The overall process provided a combination of techniques and methods that increased the final prognostic model performance, achieving relevant results and requiring a smaller amount of data when compared to the state-of-the-art fetal status assessment solutions.

The adoption of IoT for smart health applications is a relevant tool for distributed and intelligent automatic diagnostic systems. This work proposes the development of an integrated solution to monitor maternal and fetal signals for high-risk pregnancies based on IoT sensors, feature extraction based on data analytics, and an intelligent diagnostic aid system based on a 1-D convolutional neural network (CNN) classifier. The fetal heart rate and a group of maternal clinical indicators, such as the uterine tonus activity, blood pressure, heart rate, temperature, and oxygen saturation are monitored. Multiple data sources generate a significant amount of data in different formats and rates. An emergency diagnostic subsystem is proposed based on a fog computing layer and the best accuracy was 92.59% for both maternal and fetal emergency. A smart health analytics system is proposed for multiple feature extraction and the calculation of linear and nonlinear measures. Finally, a classification technique is proposed as a prediction system for maternal, fetal, and simultaneous health status classification, considering six possible outputs. Different classifiers are evaluated and a proposed CNN presented the best results, with the F1-score ranging from 0.74 to 0.91. The results are validated based on the diagnosis provided by two specialists. The results show that the proposed system is a viable solution for maternal and fetal ambulatory monitoring based on IoT.

Quality of life in general population before and during pandemic is topic need to be address by researcher in terms of mobility, self-care, usual activities, pain/discomfort and anxiety/depression. The study was carried out among Saudi population. Data were collected from general population using questionnaire during the period from 22 August 2021 to 10th January 2022. As a result, total 214 participants have included in this study. Among them prevalent age group include 40 years (n= 63, 29.4%) shadowed by the age group 25-35 (n= 61, 28.5%) while above 60 years group were least frequent (n= 1, 0.5%). On questioning the applicants whether they were satisfied with their health and how would they rate their quality of life, their answers were as follows: yes, or satisfied (n= 86, 40.2%), very Satisfied (n= 102, 47.7%) Dissatisfied (n= 11, 5.1%) and neither satisfied nor dissatisfied (n= 15, 7%). Due to pandemic, they were rate quality of life very good (n= 94, 43.9%), good (n= 63, 29.4 %) poor (n= 5, 2.3 %) and neither good and nor poor (n= 52, 24.3 %). During pandemic 96 participants feel no change in their weight but 110 participants respond that there is increase in coffee intake during the pandemic. Similarly increased in smoking habits and decrease rate in social activities (n=119,41.4%). The psychosomatic well-being of people has been interrupted by disturbing their social activities during pandemic.