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The occurrence of endocrine disrupting chemicals (EDCs) is a major issue for marine and coastal environments in the proximity of urban areas. The occurrence of EDCs in the Pearl River Delta region is well documented but specific data related to Macao is unavailable. The levels of bisphenol-A (BPA), estrone (E1), 17α-estradiol (αE2), 17β-estradiol (E2), estriol (E3), and 17α-ethynylestradiol (EE2) were measured in sediment samples collected along the coastline of Macao. BPA was found in all 45 collected samples with lower BPA concentrations associated to the presence of mangrove trees. Biodegradation assays were performed to evaluate the capacity of the microbial communities of the surveyed ecosystems to degrade BPA and its analogue BPS. Using sediments collected at a WWTP discharge point as inoculum, at a concentration of 2 mg l−1 complete removal of BPA was observed within 6 days, whereas for the same concentration BPS removal was of 95% after 10 days, which is particularly interesting since this compound is considered recalcitrant to biodegradation and likely to accumulate in the environment. Supplementation with BPA improved the degradation of bisphenol-S (BPS). Aiming at the isolation of EDCs-degrading bacteria, enrichments were established with sediments supplied with BPA, BPS, E2 and EE2, which led to the isolation of a bacterial strain, identified as Rhodoccoccus sp. ED55, able to degrade the four compounds at different extents. The isolated strain represents a valuable candidate for bioremediation of contaminated soils and waters.

The Dayingezhuang gold deposit in the Jiaodong district, eastern margin of the North China Craton is hosted in Mesozoic granitic rocks and consists of quartz-sulfide veins/veinlets and sulfide disseminations in alteration envelopes. Previous studies mainly focused on the geochronology, sources of ore-forming fluids and metals to investigate the ore genesis. However, enrichment mechanism of Au and other associated trace metals remain unclear. In this study, we present detailed textures and in-situ LA-ICP-MS trace-element compositions of different generations of pyrite, as well as EMP analysis of Au-bearing minerals to discuss the occurrence and enrichment mechanism of Au at this deposit. Three generations of pyrite (Py1, Py2 and Py3) formed during three hydrothermal ore stages (I, II, and III) at Dayingezhuang. Py1 occurs as disseminations in sericitic alteration assemblages and is characterized by low Au (mean 0.15 ppm), Ag, As and Te contents. The time-resolved depth-concentration profiles indicate that Au in Py1 mainly occurs as nanoparticles and/or micron-sized inclusions. Py2 can be further divided into the early undeformed Py2a and later Py2b, which is the product of deformed Py2a with different degrees of brittle to plastic deformation and recrystallization. Py2a in pyrite-siderite-quartz veins is relatively enriched in invisible Au (mean 0.41 ppm), Ag, As, and Te compared to Py1, and contains numerous micron-sized Au inclusions. In contrast, Py2b contains lesser invisible Au (0.21 ppm) and host abundant gold minerals along the grain boundaries and microfractures. Py3 in polymetallic sulfide veins has little Au. As a whole, Au in pyrite is positively correlated with Ag and Te, which is consistent with the results of EMP analysis showing the occurrence of Au as electrum, native gold and minor petzite in pyrite. Such evidences show that the deformation and recrystallization of auriferous Py2a potentially caused local remobilization of Au (mainly as micron-sized inclusion Au) via solid-state ductile flow and subsequent reconcentration of Au in microfractures of Py2b. The pyrite deformation and Au remobilization events were suggested to be related to the continuous reactivation of the regional Zhaoping Fault contemporaneous with gold mineralization. Our study highlights the importance of remobilization and reconcentration of Au triggered by syn-ore tectonic activities at Dayingezhuang and possibly other Au deposits in the Jiaodong district.

The prevalence of microplastics in the environment has become a major global conservation issue. One primary source of environmental microplastics is personal care and cosmetic products (PCCPs) containing microbeads. The market availability of PCCPs containing microbeads and the level of contamination of coastal sediments by microplastics was studied in one of the most densely populated cities in the world, Macao in China. We found that PCCPs containing microbeads are still widely available for sale in the region, with over 70% of surveyed PCCPs containing at least one type of microbeads as an ingredient, with polyethylene (PE) being the most common one. In an estimate, the use of PCCPs in the territory may release over 37 billion microbeads per year into the environment via wastewater treatment plants. The density of microplastics in coastal sediments varied between 259 and 1,743 items/L of sediment, amongst the highest reported in the world. The fraction of < 1 mm was the most abundant, representing an average of 98.6% of the total, and correlated positively with the abundance of larger sized fragments. The results show that although environmental pollution with microplastics released from PCCPs usage is significant, other sources, namely fragmentation of larger plastic debris, likely contribute more to the issue. The study highlights the magnitude of the problem at a local level and suggests possible mitigating strategies.

Digital Factory (DF) planning is the key of intelligent factory construction, where intelligent production technologies of big data analysis, cloud computing, blockchain, Internet of Things, artificial intelligence, 5G, Time Sensitive Network (TSN), Digital Twin (DT), additive manufacturing are included. By applying the modern techniques, DF performs great advantages on the aspects of product lifecycle management, enterprise resource planning, operation management, supply chain management, real-time database construction, advanced process control, as well as the new technologies of distributed control system and fieldbus control system. This article delivers a review of key issues of DF top-level design and planning from the aspects of networking, precision, automation and digitalization. Solutions are explored based on 5G, TSN and DT advanced technologies, literately and practically. Additionally, the article describes the method and application of efficient big data comprehensive solution. Therefore, this study contributes valuable decision-making support for DF applications.

As an emergent tourism sector, driving tourism connects car use and touristic activities intimately. Following the notion of the ‘inhabited car’, this article explores how and why Chinese tourists inhabit a travelling car for drivers/passengers in the leisure automobility and driving tourism context. Through three different road trips and ‘mobile methods’, it was found that Chinese tourists inhabit the car in four ways: driving, gazing, listening, and communicating. Through this embodied habitation, the car is turned into a ‘touristic inhabitation’ space for protecting the tourists generating touristic emotions、social interactions, and tourism meanings. The study contributes to automobility and tourism literature and provides implications for driving tourism development in China.

AimsVascular calcification is a common clinical complication of chronic kidney disease (CKD), atherosclerosis (AS), and diabetes, which is associated with increased cardiovascular morbidity and mortality in patients. The transdifferentiation of vascular smooth muscle cells (VSMCs) to an osteochondrogenic phenotype is a crucial step during vascular calcification. The transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα) plays an important role in regulating cell proliferation and differentiation, but whether it regulates the calcification of arteries and VSMCs remains unclear. Therefore, this study aims to understand the role of C/EBPα in the regulation of vascular calcification.Methods and ResultsBoth mRNA and protein expression levels of C/EBPα were significantly increased in calcified arteries from mice treated with a high dose of vitamin D3 (vD3). Upregulation of C/EBPα was also observed in the high phosphate- and calcium-induced VSMC calcification process. The siRNA-mediated knockdown of C/EBPα significantly attenuated VSMC calcification in vitro. Moreover, C/EBPα depletion in VSMCs significantly reduced the mRNA expression of the osteochondrogenic genes, e.g., sex-determining region Y-box 9 (Sox9). C/EBPα overexpression can induce SOX9 overexpression. Similar changes in the protein expression of SOX9 were also observed in VSMCs after C/EBPα depletion or overexpression. In addition, silencing of Sox9 expression significantly inhibited the phosphate- and calcium-induced VSMC calcification in vitro.ConclusionFindings in this study indicate that C/EBPα is a key regulator of the osteochondrogenic transdifferentiation of VSMCs and vascular calcification, which may represent a novel therapeutic target for vascular calcification.

Limited special education and related services are available for children with autism spectrum disorder (ASD) in Macau, especially those who are educated in general education classrooms. No intervention study has been conducted on these children. This study was conducted to explore the relationship between a board game play intervention and board game play behaviors and social communication of children with ASD educated in general education classrooms in Macau. A repeated measures design was used and the results of this study showed the mean occurrence of unprompted board game play behaviors per session during intervention was not significantly different from that during pre- or post-intervention. The mean occurrence of social communication per session during intervention was significantly higher than that during pre- and post-intervention. These findings suggest a positive relationship existed between the board game intervention used in this study and social communication of children with ASD.

The key challenge of Unsupervised Domain Adaptation (UDA) for analyzing time series data is to learn domain-invariant representations by capturing complex temporal dependencies. In addition, existing unsupervised domain adaptation methods for time series data are designed to align marginal distribution between source and target domains. However, existing UDA methods (e.g. R-DANN Purushotham et al. (2017), VRADA Purushotham et al. (2017), CoDATS Wilson et al. (2020)) neglect the conditional distribution discrepancy between two domains, leading to misclassification of the target domain. Therefore, to learn domain-invariant representations by capturing the temporal dependencies and to reduce the conditional distribution discrepancy between two domains, a novel Attentive Recurrent Adversarial Domain Adaptation with Top-k time series pseudo-labeling method called ARADA-TK is proposed in this paper. In the experiments, our proposed method was compared with the state-of-the-art UDA methods (R-DANN, VRADA and CoDATS). Experimental results on four benchmark datasets revealed that ARADA-TK achieves superior classification accuracy when it is compared to the competing methods.

This chapter describes how intellectual capital comprising human capital, structural capital, and relational capital are being created for school development and quality assurance in Macau. Macau has aimed to catch up with the global education reform by subsidising majorities of the non-tertiary sectors and promulgating Decree Laws regarding education policies and development. Despite the significance of the intangible assets of the intellectual capital, the chapter also attempts to analyse the issues and challenges towards the management of intellectual capital emerging simultaneously in the transition process in the educational context of Macau. It suggests capitalising on the accumulated school knowledge for school effectiveness. This chapter depicts the chronological development of Macau's education reform by analysing how Macau has attempted to emancipate its education institutions from the period of quasi-closed system to that of the open system by creating different types of intellectual capital in school. It discusses the emerging issues and challenges simultaneously in the transition process of educational development in Macau, namely before and after returning its sovereignty to the Chinese government.

People with intellectual disabilities need vocational training and support in order to be able to get into the work market and maintain their workplace. In Macau SAR, China, the vocational training ecosystem still operates in fully classic, in-person, fashion, which means it is susceptible to pandemic situations such as COVID-19. This causes a big disruption to the training when isolation measures are in place. Our goal is to study the introduction of serious games for vocational training of people with disabilities in Macau. This work presents a study to assess the training benefits of serious games and usability factors, understand the acceptability and adoption factors/benefits of serious games for vocational training for people with intellectual disabilities and associated stakeholders in Macau.

Resumo O fascínio do Ocidente pela dicção poética oriental está atestado em várias latitudes e línguas, e resultou numa profícua produção na área da poesia. Sabe-se que a reinvenção da poesia chinesa da autoria de Pound, em grande medida na origem da sua proposta de revolução do idioma poético, nas primeiras décadas do séc. XX, assentou, na verdade, numa falácia; numa concepção errada da natureza da escrita chinesa (e japonesa) como essencialmente pictográfica e ideogramática, na base de propriedades expressivas reconhecidas na poesia que resultariam numa particular eficácia na apreensão e tradução do real. Pessanha enaltece, em termos similares aos da exaltação poundiana, a escrita da poesia chinesa clássica. Interessa-nos rever alguns inventários dos traços da dicção poética chinesa e japonesa que explicam que ela seja tomada como metonímia e metáfora da poesia, ou como meta e utopia da poesia, para perceber o que terá levado autores muito díspares a tentar a mão nos haikus, processo em que sondaremos algumas formulações poéticas em língua portuguesa. Consideramos também que esse fascínio por uma (sonhada) origem da dicção poética, quando cruzada com o habitar (não metafórico, neste caso) do pequenino enclave de Macau, de autores que nele lançaram raízes, resultou em alguns exercícios poéticos particularmente felizes e singulares. Serão trazidos à colação nesta abordagem poemas de Eugénio de Andrade, Sophia de Mello Breyner Andresen, José Tolentino Mendonça, Yao Feng, Fernanda Dias e Fernando Sales Lopes.

Despite the prevalence of aesthetic education as one of the main developmental objectives in curricular worldwide, the mainstream philosophical discourse on its definition is predominately framed by western philosophy due to a paucity of cross-cultural studies on the subject. The article aims to achieve a contemporary understanding of aesthetic education from both the Chinese and Western aesthetic perspectives. Through the lens of postmodernism, the relationship between Daoist aesthetics and the western postmodern aesthetic perspectives, particularly the Deleuzian concept of rhizome, is identified. Both aesthetic perspectives concern de-authorship and promote self-consciousness/self-awareness. The study reconceptualises the functions of aesthetic education with the Chinese aesthetic philosophy that promotes the nurture of better people through benevolence.

It has become increasingly clear that the early use of decomposition for addition is associated with later mathematical achievement. This study examined how younger children execute a base-10 decomposition strategy to solve complex arithmetic (e.g. two-digit addition). 24 addition problems in two modalities (WA: Written Arithmetic; OA: Oral Arithmetic) with sums less than 100 were administered to 22 Japanese and 22 Singaporean 6-year-old kindergarteners. Our findings reveal that they were able to solve complex addition. For instance, Japanese kindergarteners tended to solve complex arithmetic using base-10 decomposition across the modality, whereas Singaporean kindergarteners used standard algorithms and basic counting to solve complex WA and OA problems, respectively. We speculate that Japanese kindergarteners might have a clearer understanding of the base-10 concept and were able to use this knowledge more readily than Singaporean kindergarteners. Mathematical experiences in kindergarten and number-naming systems have been put forward as two of the crucial contributors for such cross-cultural differences. This study also provides new directions for future research on the understanding of the base-10 concept and its application among young children.

The research explores the perceptions of five secondary school students with special education needs (SEN) about their participation in learning, group membership, and agency within an inclusive school in Macau SAR. This goal is achieved by using students' voices documented in open-ended interviews and is underpinned by the conceptual framework of heutagogy. The aim is to shed light on students' perceptions on school effectiveness in supporting their needs through successful participation and agentic possibilities. Findings showed that students were more prone to social rejection and being isolated or bullied than their peers. They were struggling to feel included or participate, their needs were only partially being met, and they had few opportunities to exert influence on their educational trajectories. Recommendations are provided to assist educators and schools in enhancing students with SEN to connect to the learning process and community, with the provision of appropriate learning adjustments and more active approaches to ensure their acceptance by mainstream students, including the formation of coaching peers to assist in developing social and academic skills under teacher's scaffolding practices. This study highlights the contribution of the heutagogical perspective to advance research on the participation and agency of students with SEN in mainstream schools.

This contribution to the special issue is an historical account of Paulo Freire’s pedagogical and administrative praxis before his forced exile in 1964. It relies on interviews collected during a field trip in 1976, a conversation with Paulo Freire in Geneva one year later and on the secondary literature up to date. Being the head of the first Extension Service of a major Brazilian university in the early 1960s gave Freire and his collaborators the space and time to experiment with the today world famous literacy method bearing his name. The concept of ‘Field of Cultural Production’ (Bourdieu) is used to elucidate better Freire and his team’s avant-gardist production within the spaces opened up by Brazil’s popular movements in the early sixties. The contribution shows how the ‘Paulo Freire System’ developed in the praxis of a cultural movement and received its academic consecration in an incremental and eclectic style.

The Mesozoic gold deposits in the North China Craton (NCC) were hosted by the Precambrian basement and Mesozoic intrusions. Thus, most researchers consider that these gold deposits were genetically linked to the Mesozoic intrusions. However, we suggest that a metamorphic devolatilization model provides an alternative based on a combined Fe and in-situ S isotopes study on auriferous pyrites from the Baiyun gold deposit in the NCC. The Triassic Baiyun gold deposit contains the quartz vein and altered rock ores that were developed in the Paleoproterozoic metavolcanic-sedimentary rocks (the Liaohe Group). Our in-situ S isotopic analyses show that pyrites from the quartz vein ores are characterized by negative δ34S values (-10.7 ∼ -5.5‰), while those from the altered rock ores have two distinct groups of δ34S values, one being positive (+13.5 ∼ +16.2‰) and the other negative (-10.6 ∼ -3.0‰). We suggest that pyrite grains with positive δ34S values should be relicts from the host rocks, because they show comparable δ34S values with those from the host rocks schists (+3.3 ∼ +16.1‰). Thus, only the negative δ34S values of pyrites in ores (-10.7 ∼ -3.0‰) and the Fe isotopes of the quartz vein ores (δ56Fe = +0.30 ∼ +0.48‰) can represent the isotopic characteristics of ore-forming fluids at Baiyun. Our study shows that the sulfur were probably from the pyritic volcanic-sedimentary sequences of the Liaohe Group, rather than from magmas. The calculated δ56Fe values of the ore-forming fluids (-0.78 ∼ -0.37‰; pyrite-fluid isotope fractionation) could be modelled in a metamorphic devolatilization model with Fe-species (pyrite&magnetite) of the Liaohe Group as sources. Therefore, our combined S- and Fe- isotope data indicate that the metamorphic devolatilization of the Liaohe Group could account for the genesis of the Baiyun gold deposit.

The objective of this case study is to analyze how two groups of parents, a group who have newly arrived in Macau from Mainland China and the other who have resided in Macau for more than three decades, interact with the class teachers at the levels of ?two-way communication,? ?supervision of children at home,? and ?participating in decision making? in a secondary school. The findings will redound to the benefits of school leaders, teachers, and indirectly the parents in a sense that looking closely at the ethnic and cultural differences between parents can promote effective cooperation between parents and teachers.

Medical classification is affected by many factors, and the traditional medical classification is usually restricted by factors such as too long text, numerous categories and so on. In order to solve these problems, this paper uses word vector and word vector to mine the text deeply, considering the problem of scattered key features of medical text, introducing long-term and short-term memory network to effectively retain the features of historical information in long text sequence, and using the structure of CNN to extract local features of text, through attention mechanism to obtain key features, considering the problems of many diseases, by using hierarchical classification. To stratify the disease. Combined with the above ideas, a deep DLCF model suitable for long text and multi-classification is designed. This model has obvious advantages in CMDD and other datasets. Compared with the baseline models, this model is superior to the baseline model in accuracy, recall and other indicators.